CAS No: 98-92-0
Chemical Name: 3-pyridinecarboxamide
Molecular formula: C6H6N2O
Molecular weight: 122.12
Chemical Structure:
Nicotinamide, also known as
niacinamide, vitamin PP, is the amide of nicotinic acid
(vitamin B3). It is a water-soluble vitamin and is part
of the vitamin B group.
Nicotinamide is a pyridine derivative, it is an integral
part of coenzyme I and II, both of which are coenzymes
of many deaminases, without which the normal breathing
of cells and metabolism will be interfered, thus leading
to pellagra.
Niacinamide is one of the two principal forms of the
B-complex vitamin - niacin. The term niacin is used
as a collective term to refer to both nicotinamide and
nicotinic acid, the other principal form of niacin.
Nicotinamide and nicotinic acid have identical vitamin
activities, but they have very different pharmacological
activities.
Nicotinamide, via its major metabolite NAD++ (nicotinamide
adenine dinucleotide), is involved in a wide range of
biological processes including the production of energy,
the synthesis of fatty acids, cholesterol and steroids,
signal transduction, and the maintenance of the integrity
of the genome.
Nicotinic acid, in pharmacological doses, is used as
an antihyperlipidemic agent. It also causes vasodilatation
of cutaneous blood vessels resulting in the so-called
niacin flush. Nicotinamide in pharmacological doses
does not have antihyperlipidemic activity, nor does
it cause a niacin-flush.
Nicotinamide, unlike nicotinic acid, does not have significant
effects on lipids, but it has been shown to be useful
for some with type 1 (insulin-dependent) diabetes. There
is preliminary evidence showing that it might help individuals
with generalized granuloma annular and osteoarthritis.
There is little evidence that it is helpful in rheumatoid
arthritis, schizophrenia or tinnitus. It has been suggested
that it might aid in some cancer therapies.
Nicotinamide has been shown to have antioxidant activity.
In vitro, it has been found to inhibit protein oxidation
and lipid peroxidation.
Nicotinamide has demonstrated anti-inflammatory actions
which may be of benefit in patients with inflammatory
skin conditions. These conditions include acne vulgaris.
Standards: BP2005 / USP29 /
EP5
Packing: 25kgs/drum
Storage: Keep container tightly closed.
Keep container away from light, heat in a cool, well-ventilated
area.
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